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Acute or significant bronchial bronchial asthma within an unmonitored location or in absence of resuscitative devices. (4)Cytochrome P450 3A4 Interaction. The concomitant use of Oxycodone/acetaminophen with all cytochrome P450 3A4 inhibitors may possibly lead to an increase in oxycodone plasma concentrations, which could improve or prolong adverse